TWO CASES OF DRUG-INDUCED PANCREATITIS DUE TO METHYLDOPA AND MEPHENAMIC ACID

Tetsuji AKIYAMA; Tadasu FUJI; Satoshi KONDOH; Kayoko ADACHI; Shinya TANAKA; Kenzoh HARIMA; Toshiyuki SASAKI; Ryohsuke OHMURA; Kazutaka NAKATA; Takayoshi NOGUCHI; Hideo AMANO; Tsuyoshi AIBE; Takayoshi TAKEMOTO

doi:10.11280/gee1973b.30.760

Tetsuji AKIYAMA, Tadasu FUJI, Satoshi KONDOH, Kayoko ADACHI, Shinya TANAKA, Kenzoh HARIMA, Toshiyuki SASAKI, Ryohsuke OHMURA, Kazutaka NAKATA, Takayoshi NOGUCHI, Hideo AMANO, Tsuyoshi AIBE, Takayoshi TAKEMOTO

Author information

Tetsuji AKIYAMA
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Tadasu FUJI
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Satoshi KONDOH
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Kayoko ADACHI
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Shinya TANAKA
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Kenzoh HARIMA
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Toshiyuki SASAKI
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Ryohsuke OHMURA
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Kazutaka NAKATA
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Takayoshi NOGUCHI
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Hideo AMANO
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Tsuyoshi AIBE
The First Department of Internal Medicine, Yamaguchi University School of Medicine
Takayoshi TAKEMOTO
The First Department of Internal Medicine, Yamaguchi University School of Medicine

JOURNAL FREE ACCESS

1988 Volume 30 Issue 4 Pages 760-765_1

DOI https://doi.org/10.11280/gee1973b.30.760

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Abstract

We experienced two cases of drug-induced pancreatitis. The first case caused by methyldopa was proved by challenge test, and the second case by mephenamic acid was proved by lymphocyte stimulating test. The former developed epigastric pain associated with hyperamylasemia, and the latter presented with frequent vomiting after meal. These symptoms were similar to those of alcoholic pancreatitis. Nine cases of methyldopainduced pancreatitis have already been reported in the world. On the other hand, mephenamic acid has not been previously reported as a cause of pancreatitis.

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