1988 Volume 30 Issue 5 Pages 893-906_1
Strip biopsy is an endoscopic mucosal tissue excision technique that also contains the submucosal tissue, and the size of the specimen is almost always 1-3 cm. This technique neccesarily causes an artificial ulcer of Ul II at the site of excision. In this study, we examined 84 lesions endoscopically and 39 lesions of post strip biopsy ulceration histologically. The period from excision to scarring confirmed by both endoscopy and operated specimen was nearly 30 days. The period was unrelated to the location of the artificial ulcer. When regenerating epithelium covered the ulceration entirely, the mucous gland were already formed and the secretion actively. The time of regenerating the muscularis mucosae took nearly 100 days. Fold convergency of the artificial ulcer begins from the 7 th day according to the endoscopic finding. The shape of the histological cross section is trapezoid and the grade of the fold convergency of this lesion tends to be severe. This type tends to be observed mainly in the antrum. Strip biopsy induced human gastric ulcer is considered to be a model of regeneration of the epithelium, muscularis mucosae, and fibrous tissue, and it seems to be significant as a control to evaluate the healing process of peptic ulcer.
