CLINICAL STUDY OF ENDOSCOPIC INJECTIONOF OK-432 FOR UNRESECTABLE GASTRIC CANCER

Abstract

Nine patients of unresectable gastric cancer were treated by both endoscopic and intradermal injections of OK-432. Roentgenographic and endoscopic examinations revealed morphological improvement in two of them. One case was Borrmann 1 type advanced cancer and another case was IIa +IIc type early gastric cancer. In these cases the tumor masses disappeared completely, and in the latter case no cancerous tissue was detected by biopsy examination. Fever (38 to 39°C) was noted four to five hours after the endoscopic injection of OK-432 in all cases. But there was no serious side effect of this therapy except fever. Local administration of OK-432 by endoscopic injection is effective and recommended for the treatment of unresectable gastric cancer.