Abstract
The combined method of direct-coating with sucralfate-thrombin mixture and H2 blocker administration was performed to 87 cases showing upper gastrointestinal hemorrhage. Patients ranged from 20 to 93 of age. The mean age in males (62 cases) and females (25 cases) was 59 and 65 years of age, respectively. There were 31 cases (36%) of gastric ulcer, 22 (25%) of duodenal ulcer, 6 (7%) of stomal ulcer, 13 (15%) of acute gastric mucosal lesion, 8 (9%) of gastric cancer and 7 (8%) of other diseases (Mallory-Weiss syndrome 2, submucosal tumor 1, post-polypectomy 4). Forty three cases (49%) had severe primary diseases and 8 cases (9%) died from other causes. In twenty four cases (28%), severe epigastralgia was shown at emergency endoscopy. Endoscopic findings on an ulcer base were as follows : without blood clots, 12 cases (14%) ; with fresh blood clots, 40 cases (46%); oozing, 17 cases (20%); capillary blood vessels, 14 cases (16%) ; exposed vessels, 4 cases (5%). Hemostatic rates in this method was 100%. Complete and temporary hemostatic effect was obtained in 85 cases (98%) and 2 cases (2%), respectively. Furthermore, severe epigastralgia in 24 cases (28%) was disappeared immediately after direct-coating therapy. The results indicate that drug direct-coating method using endoscopic hemostasis are valuable for upper gastrointestinal hemorrhage and also effective to alleviate symptoms (epigastralgia and so on).
