Abstract
To investigate the characteristics of atrophic gastritis in patients with hyperplastic polyp of the stomach (HP), indirect methylene blue staining was performed, and gastric acid secretion and serum gastrin level were examined in 61 patients with HP, 9 with gastric adenoma, 8 with protruded type early gastric cancer and 20 with atrophic gastritis (MAO<5mEq/h) which had otherwise no gastric lesions. The development of intestinal metaplasia was severe in the antrum, and antral, extensive or diffuse type, in which intestinal metaplasia extended from the antrum, was common in patients with gastric neoplastic lesion (adenoma or early cancer) and atrophic gastritis. On the other hand, intestinal metaplasia was slight or absent in the antrum, and three types including non-metaplastic, intermediate and fundic type, were more frequent in patients with HP than in those with others. Moreover, serum gastrin level was significant-ly higher in the former than in the latter, although hypochrolhydria or achrolhydria was common in all diseases studied. From the results obtained, it was proved that the location and development of atrophic gastritis in patients with HP was different from that in those with gastric adenoma, protruded type early gastric cancer and atrophic gastritis, although the relation to atrophic gastritis had been previously described in all diseases studied.
