Abstract
A case of mefenamic acid induced colitis associated with multiple ulcers in the terminal ileum was reported. A 52-year-old male was admitted to our hospital with chief complaints of abdominal pain, diarrhea and bloody stool. He had a history of having taken mefenamic acid (Pontal) 1.5 g/day for past 8 years. Colonoscopy revealed aphthoid colitis and multiple hemorr-hagic ulcers in the terminal ileum. Biopsy specimens taken from the surroundings of these ulcers demonstrated marked round cell infiltration in the submucosa accompanied by proliferation of lymph follicles. Mefenamic acid was immediately discontinued after admission. The colitis healed on the 24th hospital day and the multiple ulcers scarred on the 70th hospital day. After discharge he took mefenamic acid again. He then developed diarrhea and abdominal pain. Colonoscopy revealed the relapse of aphthoid colitis. Therefore, mefenamic acid was considered as the cause of aphthoid colitis and multiple ulcers in the terminal ileum.
