A CASE OF ICG EXCRETORY DEFECT ACCOMPANIED BY CHRONIC TYPE B HEPATITIS

-THE LAPAROSCOPIC FINDINGS AFTER A HIGH-DOSE ICG ADMINISTRATION-

Abstract

A 32-year-old male, a HB virus carrier (eAb positive), was hospitalized with general fatigue and liver dysfunction. Laboratory data revealed a slight elevation of serum GPT level and an abnormality of serum thymol turbidity test. ICG test showed an extremely high retention at 15 minites such as 86, 90, and 73%, a low disappearance rate and a low plasma-liver transfer rate constant while BSP test showed a slight abnormality. On laparoscopic examination, reddish patchies as well as partly nodular formation were recognized on the liver surface and little ICG coloration after intravenous ICG injection even in a dose of 3mg/kg was observed. Light microscopic findings were compatible with chronic inactive hepatitis. However, on the electron microscopic examination, an increase of collagen fiber in the Disse's space, a flattering of fuzzy lining of the liver cell, a basement membrane formation of the Disse's space and a deformity of mitochondrias were seen. Those morphological findings were suggested to be associated with a mechanism of ICG excretory defect.