Abstract
A basic study was carried out with Cyanoacrylate (ethyl-α-cyanoacrylate) which is used as a tissue adhesive agent, in order to evaluate clinical application as a sclerosing agent. When it was injected into a vessel of rabbit's ear, rapid coagulation was observed producing localized acute inflammation, but neither deciduation of intravascular endothelial cells nor thrombosis was induced. When it was injected submucosa of esophagus and stomach of the dogs, similar changes were induced. When Cyanoacrylate alone was used clinically, varices was not improved. It seemed difficult that single use of Cyanoacrylate improve varices. Therefore, simulataneous administration of Cyanoacrylate and Etanolamine Oleate seemed to be indicated. Since Cyanoacrylate polymerizes Eth-anolamine Oleate in the puncture needle in an instant when the later is injected following the injection of the former, it is important that Ethanolamine Oleate be washed away thoroughly with 5% glucose after injection. Considering the properties of Cyanoacrylate, it should be used for such purposes as hematemesis in the event of esophageal varix rupture, or as prevention of bleeding upon removal of the puncture needle.
