Abstract
To assess the characteristics of the gastric mucosa in patients with gastric foveolar hyperplastic polyp (HP), the determination of gastric acid secretion, serum gastrin levels, and serum pepsinogen I (PGI) levels were undertaken in 128 patients with HP and in 230 controls who had no gastric lesion. Moreover, the differences of the state of gastric mucosa were studied in patients with HP, according to the number and the location of the polyp. The following were the results of our investigations. 1) Hypochlorhydria or achrolhydria, hypergastrinemia, and hypopepsinogenemia I was more common in patients with HP than in controls. 2) Gastric acid secretion was significantly lower and serum gastrin levels were significantly higher in the case with solitary polyp than in that with multiple polyps. 3) As to the location of the polyp, serum gastrin levels were significantly higher and serum PGI was significantly lower in the case with the polyp located in the fundic mucosa than in that with the one located in the pyloric mucosa. From the results obtained, atrophic gastritis of the fundus was common in patients with HP. However, the development of antral gastritis was different according to the number or the location of the polyp.
