Abstract
The patient was 28-year-old man complaining of watery diarrhea. On January in 1985, edema appeared in his legs and he was diagnosed nephrotic syndrome. As watery diarrhea appeared at several times a day in June of 1986, he was admitted in January of 1987. He was diagnosed Crohn's disease on X-ray, endoscopic examination and biopsy. At the same time, amyloid deposition was observed in the submucosal layer of the rectum. Amyloid analysis showed AA type amyloid deposition which is usually seen secondary amyloidosis. However, other comsumptive diseases were not recognized. So that he was diagnosed secondary amyloidosis due to Crohn's disease. The patient was an interesting case preceded by symptoms of nephrotic syndrome due to renal amyloidosis 18 months before diagnosis of Crohn's disease.