Abstract
We reported a case of drug induced liver injury showing potato-like liver caused by herb drug.
A 28-year-old male took a herb drug "Sakaki Gachyagi's Drug" for the common cold-like symptom. About 2 weeks later after discontinuance of drug, he experienced easy fatigability, anorexia, jaundice and eruptions associated with severe itching. He had no history of blood transfusion. On admission, hepatic encephalopathy was not detected, but prothrombin time showed marked low value of 33.6%. The examinations for the viral antibodies were negative. Lymphocyte stimulating test was positive when "Sakaki Gachyagi's Drug" was added (Stimulation Index 207%). Laparoscopy showed severe necrosis and atrophy in the left lobe and typical potato-like liver appearance in the right lobe of the liver. The liver biopsy specimen revealed a submassive hepatic necrosis accompanied by proliferation of connective tissue and moderate inflammatory cell infiltra-tion at the portal area and bolooning, degeneration and necrosis of the hepatocytes at the parenchymal tissue.
