Abstract
In order to minimize the complaints of patients in laparoscopy, we have attempted to use a neuroleptanalgesia-modified (NLA-mod) anesthesia using diazepam and pentazocine, and compared its efficacy and side effects with those of NO2 inhalation anesthesia and local anesthesia. Subjects were 60 patients with liver diseases, to each 20 of whom a type of three anesthesias was randomly selected. Evaluation of each anesthesia was done by questionnaire for the complaints during examination and 24 hours after thet. Changes in blood pressure, heart rate (all cases) and arterial blood gas analysis (some cases) were measured during examination and changes in biochemical data were also checked one week after examination. Following results were obtained. (1) NLA-mod was effective for minimizing the complaints in laparoscopy compared with other types of anesthesia. Especially, total discomfort during examination and abdominal fulness both during and after examination were significantly reduced under NLA-mod than local anesthesia. (2) Changes in blood pressure under NLA-mod were less than the other anesthesias, and changes in blood gas analysis under NLA-mod were similar to local anesthesia. No cases of drug-induced liver injury were noticed.
