ENDOSCOPIC EVALUATION OF GASTRIC ULCERS SHOWING MUCOSAL PROTRUDING CHANGE IN ULCER FLOOR AT HEALING PROCESS

Abstract

From January 1983 to October 1986, we observed 8 patients with gastric ulcer which showed mucosal protruding changes in ulcer floor at the healing process. The incidence is 1.8% . A ratio of male to female was 7 : 1. A mean of age was 64 years, ranged 49 to 75. Seven of the patients had hematemesis or melena. The most common site of the lesions was the angulus of the stomach. The size of the ulcers in 5 patients were above 2cm in diameter. Seven patients were treated with cimetidine and a patient with famotidine. Gastric ulcers with mucosal protruding changes tended to be large in size and old in age, compared with those in control group. Most of mucosal protruding lesions appeared in 4 to 7 weeks after the active stage of the ulcers. Histological examination of biopsy specimens obtained from protruding lesions showed the presence of granulation tissue. We classified the protruding lesions into 3 types according to their shapes. The days required to improve from the active stage to the scarring stage were longer in these 8 patients than in control group. It was suggested that these protruding lesions would develop due to unusual rapid repairment and over growth of granulation tissue of ulcer floor.