Abstract
We reported a case of Ménétrier's disease diagnosed with endoscopic ultrasonography (EUS), strip biopsy and 99mTc-DTPA-HSA scanning after administration of albumin. A 35-year-old male was admitted with a chief complaint of pretibial edema. Labora-tory data showed hypoproteinemia and iron deficiency. Huge gastric folds were observed on an upper GI study and endoscopic examination. EUS showed huge gastric folds to be due to thickening of the 1st and 2nd layer of the gastric wall without any abnormality in other layers. The histopathological specimen obtained by the endoscopic strip biopsy revealed the huge gastric folds consistent with hyperplasia of the foveolar epithelium. To demonstrate the leakage of protein from the stomach, radioisotopic (RI) study with 99mTc-DTPA-HSA after intravenous administration of albumin was performed. RI activity was present in the stomach and the small intestine on the sequential RI study, confirming the leakage of protein. This patient was diagnosed as Ménétrier's disease from the findings of EUS, strip biopsy and 99mTc-DTPA-HSA after intravenous administration of albumin. These three studies were useful for the diagnosis of Ménétrier's disease.
