Abstract
It is well known as malignant cycle that early gastric cancer often changes its form from ulcerative lesion to scar. We report that a III+IIc type early gastric cancer developed protruding lesion without depressed lesion and changed to IIc+IIa type. A 79-year-old man was pointed out ulcerative lesion at the angular region of the posterior wall of the stomach by endoscopic examination. After administration of anti-ulcerogenic agents such as H2 blocker, the lesion improved completely for two months, then 4 months later we found the apparent protruded lesion at the same region. The specimen of biopsy obtained from the protruded lesion revealed well differenciated adenocarcinoma. After that, the protruded lesion suddenly decresed in size and the diagnosis of IIc+IIa type early gastric cancer was made. Resected specimen showed massive fibrosis in the submucosal layer and adenocarcinoma limited to the mucosal layer. From the result of histological study, we considered the protrude lesion consisted of cancerous cells.
