TWO CASES OF CRONKHITE-CANADA SYNDROME IMPROVED MARKEDLY WITH STEROID THERAPY

Abstract

We reported two cases of Cronkhite-Canada syndrome improved markedly with steroid therapy. The first case was 43-year old male and the second was 58-year old male. In both cases, diarrhea, generalized gastrointestinal polyposis, alopecia, onychotrophia, skin pigmentation and hypoproteinemia were found. Histological examination of biopsy specimens from polyps revealed cystic dilatation of the glands, edema of the lamina propria and inflammatory cellular infiltration. No especial changes of clinical manifestations were seen with conventional treatment such as elemental diet and albumin transfusion, but ectodermal abnomalities and polyposis improved remarkably with steroid therapy in both cases.