1992 Volume 34 Issue 4 Pages 879-887
A 21-year-old female was hospitalized because of abdminal pain and bloody stool in 1984. Colonoscopic findings showed multiple small erosions and lead pipe finding was shown by barium enema. These findings were compatible with ulcerative colitis (UC). The patient's younger identical twins brothers, 19-year-old males, were also hospitalized because of diarrhea and bloody stool in 1989. The similar multiple small erosions were shown by colonscopy as in the sister. These findings suggested a familial occurrence of ulcerative colitis. HLA-BW52, DR2, DQW1 were found in the sister and her twin brothers by HLA analysis. We presented the above mentioned three cases, because there have been no reports like this familial occurrence of UC, especially three persons occuring in the same family.
