A STUDY ON THE WHITISH PROTRUSION APPEARING IN THE BASE OF PEPTIC ULCER DURING THE ADMINISTRATION OF PRONTONPUMP INHIBITOR

Abstract

Endoscopic findings of 52 cases with peptic ulcer treated with proton-pump inhibitor (PPI) were studied with special reference to whitish protrusion in ulcer base. Subjects were 40 cases with gastric ulcer, 11 cases with duodenal ulcer, and one case with stomal ulcer. In 7 cases with gastric ulcer, whitish protrusions appeared after 4.6 weeks of treatment on the average and in a case of stomal ulcer, whitish protrusions appeared after 2 weeks. In cases with duodenal ulcer, no whitish protrusions appeared. In 3 cases with gastric ulcer, whitish protrusions disappeared eight weeks later and in a case, whitish protrusion developed and transformed to reddish protrusion. In the remaining 3 cases with gastric ulcer, whitish protrusions developed but still remained. The gastric ulcers with whitish protrusion were reccurent in 6 cases and located in the middle body of the stomach in 5 cases. The histological findings of biopsy specimens taken from the whitish protrusions showed granulation tissue with marked infiltration of neutrophils and lymphocytes. The whitish protrusions developed and transformed to reddish protrusions or disappeared after administration of PPI.