EXPERIMENTAL COLITIS IN RATS RESEMBLING HUMAN ULCERATIVE COLITIS

Abstract

We made acute colitis model with 5 %DSS and chronic colitis model with 2 % DSSEndoscopic, pathological and fecal bacteriologic findings of these models were studied.The results were as follows ;I. Acute colitis model1 On the endoscopic study of the 7th day, ulcers and blood were seen in the rectum of rats.2 On the pathological study, strong inflammation in the rectum of rats and weaker inflammation in the colon than the rectum were seen.3 On the concentrations of SOD activity and leukotriens in the tissues of the colon, the concentrations in the colon of colitis rats tended to be higher than those of normal rats, but therwas no significant difference between them.II. Chronic colitis modelOn the endoscopic and pathological studies, the grades of inflammation on the chronic colitis models were lower than those of the acute colitis models.