Abstract
A 21-year-old man was transfered to our division because of massive hematemesis. He was to be agranulocytosis after two cycles of combination chemotherapy with Cisplatine, Etoposide and Bleomycin, and was also treated with bone marrow transplantation and G-CSF for mediastinal embryonal carcinoma. At the same time, he got fever and had chest pain. Some days after, he vomited blood. Emergency upper gastrointestinal endoscopy disclosed diffuse ulcers and active bleeding in the thoracic esophagus. Biopsy studies did not show any infections of candida, bacterium or virus. The ulcers healed up by conservative treatment. These diffuse ulcers may be due to immunodef iciency state or agranulocytosis origined after intensive chemotherapy. This paper presented a case of diffuse esophageal ulcers with agranulocytosis due to anticancer chemotherapy.
