THE EFFECT OF UPPER GASTROINTESTINAL ENDOSCOPY ON SERUM GASTRIN LEVELS

Abstract

Serum gastrin levels were measured before and after upper GI endoscopy in 178 patients, to clarify the influence of the endoscopy on serum gastrin levels. Serum gastrin levels after endoscopy elevated significantly by scopolamine butylbromide injection as a premedication, decreased significantly by glucagon injection and was not influenced significantly with no premidication. Gastric biopsy procedure was suggested not to influence on serum gastrin levels after endoscopy. Presence or absence of Helicobacter pylori was also suggested not to give significant changes in serum gastrin levels during endoscopy. In most cases, changes were within±30% of the level of pre-endoscopy, and the influence of premedication of butylscopolamine bromide were disappeared 30 minutes after endoscopy. Therefore, it was suggested that there was no practical problems to regard serum gastrin levels of after-endoscopy as the basal levels.