Abstract
Chemical lymph nodes dissection was attempted with multiphasic emulsion (W/O/W) containing either epirubicin (EPI) or doxifluridine (5'DFUR) as an adjuvant chemotherapy after endoscopic therapy for early gastric cancer. The W/O/W emulsion showed good stability and an average particle size of 2.63μm. In a study using colon 26 cancer-bearing BALB/c mice, improvement of targeting tumor was confirmed. In a clinical study with the administration of the EPI W/O/W emulsion into the peripheral gastric walls of the tumor in 30 patients with gastric cancer, a concentration of 244±240 ng/g in the targeting regional lymph nodes was found for as long as 5 days after administration. Oral adminis-tration of the 5'DFUR W/O/W emulsion in 20 patients with gastric cancer revealed that the concentrations of 5-FU were approximately 30-fold in gastric cancer tissues and approximately 20-fold in the regional lymph nodes in comparison with oral admisintration of the 5'DFUR capsules. The targeting of the tumor was excellent ; lymph node targeting was greatly improved and it is also possible that it resulted in a reduction of side effects. This emulsion should be used for adjuvant chemotherapy under endoscopy in the future.
