Abstract
A 83-year-old woman was admitted with a complaint of melena. Besides the early gastric cancer and the gastric ulcer, a deposition of black pigment from the bulb to the second part of duodenum was observed and it was diagnosed as melanosis duodeni by the histochemical and electromicroscopic examinations. The medical observation has been done for 18 months continuing the endoscopic therapy for the cancer and simultaneously with the ulcer healing to scar formation, the pigmentation disappeared. As she has been taking hydralazine hydrochloride, metoprorol, isosorbide dinitrate, it is suggested to be a possibility that the upper gastrointestinal hemorrhage induced the pigmentation under the effects of these drugs.
