Abstract
A-64-year old breast cancer patient was admitted to our hospital for post-operative chemotherapy due to bone metastasis. She was operated on 5 years before. We administered to her Adriamycin (ADR), 5-Fluorouracil (5-FU), Cyclophosphamide (CPA) and Medroxyprogesterone Acetate (MPA).
After administering a total dose of ADR (90mg), 5-FU (1500mg), CPA (900mg), and MPA (14400mg), she developed nausea, vomiting, chest pain and hematemesis. Endoscopic examination revealed mucosal dissection of posterior wall of the esophagus extending from E-G Junction to the upper part of the esophagus. Conservative management with IVH and administration of antacid drugs improved her clinical course gradually. Follow up endoscopic examination 1 month after hematemes revealed restoration of esophageal membrane.
