Abstract
The case Wasa 49-years-old male who visited our hospital complaining of decreased body weight and anorexia. Laboratory data on admission showed hypoalbuminemia and gastroendoscopy revealed hypertrophic mucasa in the gastricbody. Gastric juice analysis revealed hypoacidity and protein losing. This case was diagnosed as Menetrier's disease. Improvement was obtained by the treatment with famotidine and enteral tube elemental diet therapy. Serum pepsinogen (abbreviated as PG hereinafter) of the patient was determined before and after the treatment. Before the treatment, serum PG- and PG-II were both at abnormally high values, but the numbtrof cells containing PG granules decreased in the gastric mucosa. The difference between serum and gastric mucosa in PG-cotent was revealed. After the treatment, serum PG levels and distribution of PG granules in the gastric mucosa became normalized. This case was interesting from the point of view of elucidating the mechanism of transmigration of PG to the blood.
