1995 Volume 37 Issue 4 Pages 760-766_1
To examine the diagnostic significance of endoscopic findings, location, sex and age in 76 1esions of sessile colorectal polyps. we conducted statistical analysis of chi-square test, correlation analysis and logistic regression. Degree of histolagieal atypism corresponding to response variables was divided into mild and severe ones. The farmer indicates the atypism corresponding to adenoma with mild or moderate atypia and the latter to adenomawith severe atypia or early cancer. The endoscepic findings corresponding to explanatoryvariables were classified into two or three degrees according to the grade. With chi-squaretest for independence, the following 7 endoscopic findings were significant (p=0.05) tohistolagical atypism;size, depression, expansiveness, erosion, unclear lobulatian, whitespots and polyp on polyp appearance. For the following analysis, either of degrees numbers (0, 1 or 0, 1, 2, ) were allocated to the above 7 findings, according to the estimated risk formalignancy. With correlation analysis examined on the 7 findings, expansiveness andunclear lobulation were the significant variables related to histological atypism (γ =0.58respectively) and depression is not so much correlated(γ =0.4), indicating that sessilepolyps show both expansiveness and unclear lobulation endoscopically, in proportion to the degree of histolagical atypism, but not in case of depression. With logistic regression of multivariate analysis, Odds'ratio, the risk that polyps are alternatively diagnosed frommild to severe atypism, are 27 times on depression, 5.3 times on expansiveness, 3.7times on erosiorl and 3.6times on size, respectively. These results suggest that depression can be regarded as a highly risky finding for severe histological atypism, but it's very low incidence in the severe atypism. The expansiveness can be also regarded as a highly risky finding for malignancy. It ofteraccompany the finding of unciear lobulation, which is rued out as a confounding factor atthe logistic regression analysis. The findings of erosiveness and larger size are alsoassessed as high risk far severe atypism, as most of the papers pointed out.
