1995 Volume 37 Issue 4 Pages 805-811_1
A 53 yr. -old man with Cronkhite-Canada syndrome is described. He was performed right hemicolectomy, 3 years after the onset of syndrome, due to complication with intussusception for attributable large cecal labuleus polyp. The size of resected giant polypwas 6.5cm× 6.0cm in diameter. Other 4 pedunculated polyps measured up to 1.0cm eachother. Histological fendings of the resected specimen of the colon polyps showed expandededematous lamina propria with inflammatory cell infiltration and cystic glands resembled “ Juvenile polyps” . Two of these polyps showed definite adenamatous changes at thesurface epithelium. However, there were no evidence of adenoma or cancer involving alarge cecal lobulous polyp. Currently his postoperative course is uneventful.
We analyzed association with adenoma or cancer of the colon in Cronkhite-Canadasyndrome in Japanese literature reviewed before 1993, Twenty-eight of 211 patients with Cronkhite-Canada syndrome had associated carcinomas (13.3%) and 20 of them (9.5%) had associated with adenoma of the colon respectively. Cronkhite-Canada syndrome complicated with intussusception, all led to surgical management, has been reported in only 4 cases.
Although generally accepted as a benign disease, the Cronkhite-Canada syndrome, may be a premalignant disorder. The potential risk of cancer is not an indication forcolectomy, however, surgical intervention will be carried out at an early and appropriate stage for complications of Cronkhite-Canada syndrome such as prolapse, intussusception, bowel obstruction and sulspection of malignancy for giant polyp.
