1995 Volume 37 Issue 6 Pages 1136-1141
In order to clarify the relationship between HCV status (genotype and titer of HCV-RNA) and peritoneoscopic findings in chronic hepatitis C (CHC), 50 patients were studied (HCV genotype II: 30 patients, III: 14 patients and II+III:6 patients) . There were no significant differences in the incidence of Shimada's code number (200, 300), reddish marking (RM) and patchy marking (PM) among three groups with HCV genotype II, III and II+III. The number of patients with RM and PM was 4, those with PM alone was 8, those with RM alone was 8, and those without RM or PM was 30. The HCV-RNA titer of patients without RM or PM was signicantly lower (P< 0.05, P< 0.01, P< 0.01, respec-tively) than that of other groups. The HCV-RNA titer in patients with sublobular hepatic necrosis (SN) was significantly higher than that without SN (P< 0.05) . Among patients with SN, HCV-RNA titer in patients with PM and/or PM was signicantly higher (P< 0.05) than that without RM or PM, and it showed significantly lower (P< 0.05) complete response rate by IFN therapy than that in patients with non-SN without RM or PM. These data suggest that RM and PM reflect the high titer of HCV-RNA in CHC and useful for predicting the effect of IFN therapy.
