Abstract
A case of Epstein-Barr virus (EBV)-associated early gastric carcinoma is reported. The patient was a 60-year-old male with upper abdominal discomfort. Endoscopic and endosonographic examination revealed a protruded type of gastric carcinoma invading into the submucosal layer, therefore, surgical resection was performed. Histologically, the tumor was a mixed carcinoma showing features of both diffuse type and intestinal type. Poorly differentiated adenocarcinoma with lymphoid stroma was found in the submucosal invasive area and well-differentiated component coexisted in the mucosa. EBV was detected in the nuclei of almost all carcinoma cells by in situ hybridization for EBV-encoded small RNA 1. The high association of EBV with gastric carcinoma with lymphoid stroma has already been reported, but EBV-associated well-differentiated carcinoma is rare. This case suggests the process of neoplastic development from intestinal type to diffuse type in EBV-associated gastric carcinoma.
