Abstract
A 46myear-old female was found to have a suhmucosal tumor with ulceration in thebody of the stomach on endoscopic examination. wedge resection of the. stomach wasundergone. Grossly, the tumor was a 20 X 12 X 6mm in site with white-yellowish eutsurface.On histological examination, it consisted of polygonal cells with granular eosinophiliccytoplasm. The granules were positive for PAS, and not offacted by diastase pretreatment.Immuunohistochernical investigation revealed positive staining for 5-100 protein. Ultrastructurally, it consisted of electric-dense granules in the cytoplasm. Final diagnosis wasmalignant granular cell tumor, because it showed 3-5 mitotic figures/10 HPF and venousinvasion. To our knowledge, a granular cell tumor with venous invasion has not beenpreviously reported.
