Abstract
One hundred twenty-one specimens resected from patients with depressed type earlygastric cancer (differentiated type:70 case, undifferentiated type:51 case) were investigated by staring with the CD34 monoclonal antibody which expressed by endothelium. wetried quantified mucosal microvascular density using computer arialysis. The ratio ofmicrovascular density in cancer tissues to those of surrounding noncancerous tissues arecalculated as C/N ratio, and investigated the relation to the histologic subtypes and thecolor of endscopic findings. As a result, differentiated carcinomas were significanthypervascular (compared to the C/N ratio of undifferentiated carcinomas) . The C/N ratios are significantly different (among the three groups in color of endoscopic findigswhich are redness group, unchangeable group and pale group) . Therefore the color ofendoscopic findings was intimately concerned with the mucosal microvascular density;most of the differentiated type were hypervascuiar and redness, and most of the undifferentated type were hypovascular and pale. These findings supprated that our method ofquantified microvascular density using computer analysis is very simple and useful tocompare that between cancerous and surrounding noncancerous tissues.
