Abstract
A 51-year-old female was admitted to a hospital, because of general tiredness, hypogeusia, diarrhea, anorexia, alopecia, and onychadystrophy in September 1994. Thelaboratory data showed anemia and hypoproteinemia. Endoscopic and fluoroscopic examinations of the gastrointestinal tract showed multiple hyperplastic polyposis in the stomachand small and Iarge bowe1. Administration of predonisolone, (30mg/day)for 2 months, vvasnot effective. In May 1995, she was introduced to our hospital. On admission, colonicinvagination from the ascending colon to the right transverse colon was detected initiallyby ultrasonography. Histologie examination of biopsy specimens from polyp in the caecumrevealed hyperplastic changes of intestinal epithelium, edema and inflammatory cell infiltration, such as lymphocyte and eosinocyte, in the interstitiurn. On the basis of thesefindings, she was diagnosed as Cronkhite-Canada syndrome complicated with colonicinvagination. After treatment by steroid pulse therapy, subjective symptom, alopecia, onychodestrophy, hypoproteinemia and invagination improved gradually. The multiplepolyposis of gastrointestinal tract diminished and almost disappeared. Until now, she isimproving weld and has no recurrence.
