1998 Volume 40 Issue 10 Pages 1872-1878
A case of early duodenal carcionoma arising from Brunner's glands was reported. Thepatient was a 55-year-old woman. Upper gastrointestinal endoscopy of general healthscreening revealed a submucosal tumor-like elevated lesion with a central depression andbridging folds in the 2nd portion of the duodenum. Biopsy disclosed well differentiatedadenocarcinoma. Hypotonic duodenography also revealed an elevated lesion, 20 × 17mm insize, in the same position. Abdominal US, CT and ERCP showed no abnomality. Partialduodenectomy was performed. Pathological examination of the resected specimen showedthat well differentiated adenocarcinoma with submucosal invasion(sm)was present in apart of the Brunnerioma. This case was, therefore, diagnosed as carcinoma of Brunner'sglands origin by histochemical study using galactose oxidase-cold thionin Schiff andparadoxical concanavalin A staining. Duodenal carcinoma arising from Brunner's glandsis extremely rare. We studied 24 similar cases reported in Japan.
