1999 Volume 41 Issue 7 Pages 1313-1317
We reported a case of Cowden's disease accompanied by ganglionerofibroma and protein-losing enteropathy. A 48-year-old male visited our hospital for the examination of edema. He had iron-deficiency anemia and low-proteinemia. The examination of the gastrointestinal tract revealed polyposis of the esophagus, stomach and small and large intestines. The pathologic diagnosis was that the lesions were mainly hyperplastic. There was a large polyp in the cecum. It was a ganglioneurofibroma. Small facial papules and palmoplantar keratosis were also observed. 99mTc-DTPA binding human serum albumin Scintigraphy revealed protein losing in the colon from the cecum to the transverse colon.