Abstract
A 57-year-old man who had been suffered from relapsing gastric ulcer on the posterior wall of the upper body received eradication of Helicobacter pylori (HP) with LPZ, AMPC, and CAM in December 1994. While HP eradication had been successful, the gastric ulcer relapsed at the same site in July 1996. In September 1998, gastric ulcer relapsed again at the same site, and histological findings of the biopsy specimen around the ulcer revealed adenocarcinoma. At this time HP analysis were still negative. Although the ulcer became scar by the therapy with LPZ alone. About 4 weeks later, total gastrectomy was done in October 1998, as cancerous tissue was widely spread in the mucosa of the upper body of the stomach. This case suggested that gastric cancer might be developing, if gastric ulcer relapses after successful eradication of HP.
