Abstract
Colonoscopic findings and distribution of drug-induced colitis are various by sort and form of drugs or preexisting diseases. We herein reported two cases of colonic ulcerations induced by slow release-NSAIDs in patients with rheumatoid arthritis. A 71-year-old female(case 1) and 54-year-old female(case 2)were given a slow-release indomethacin, 25mg twice a day, and slow-release diclofenac, 37.5mg twice a day, respectively. Colonoscopy of both cases revealed multiple irregular or round ulcerations, in the cecum and ascending colon, Which were cured by the cessation of drug. We reviewed the literature of NSAIDs-illduced colonic ulcerations (40 cases; 17 males and 23 females). Colonic ulcerations in four fifth of the patients located in the right colon. The majority of causative NSAIDs were diclofenac and indomethacin, especially slow-release drugs.
