A CASE OF MALIGNANT PANCREATIC ENDOCRINE TUMOR WITH WIDESPREAD INVASION TO THE 2ND PART OF THE DUODENUM

Abstract

A 25-year-old man, who had admitted to other hospital with a complaint of abdominal pain, was transferred to our hospital for the further examination and therapy. Duodenoscopic examination showed the tumor at the 2nd part of the duodenum. Abdominal CT, MRI and angiography showed an 8-cm sized hypervascular tumor in the head of the pancreas. Serum concentrations of gastrin, glucagon and VIP were slightly elevated. Biopsy specimen showed malignant endocrine tumor and pylorus preserving pancreaticoduodenostomy was performed. The histological diagnosis was malignant endocrine tumor of the pancreas. Immunohisto-chemical examination of the tumor revealed positive immunoreactivity for ACTH, glucagons and VIP. We report a rare case of the malignant endocrine tumor of the pancreas with widespread invasion to the 2nd part of the duodenum.