Abstract
Morbid obesity is one of major health problems. We have first experienced two patients with treatment-resistant obesity treated by intragastric balloon (BioEnterics(R) Intragastric Balloon System) in Japan. Four hundred milliliters of physiological saline was injected into the intragastric balloon in each patient. Four months or 3 months later, excess weight loss of -33.4% or -19.3% was achieved, respectively, and hypertension and hyperlipidemia were also improved with no specific complications. For patients with treatment-resistant obesity, the intragastric balloon appears to be safe and useful.