2007 Volume 49 Issue 12 Pages 2953-2961
We experienced fourteen cases of basaloid carcinoma and analyzed their endoscopic diagnoses, clinicopathological characteristics and results of treatment and the average age was 66 years old, only one was female. The locations of the tumor were ; nine cases of middle thoracic esophagus (Mt), three cases of lower thoracic esophagus (Lt), one case of cervical esophagus (Ce), and one case of abdominal esophagus (Ae). The tumor types were ; seven cases of a superficial type (0-I sep ; three cases, 0-I pl ; one case, 0-I p ; two case and 0-II a +II c ; one case ; all of them were of a protruding type), and seven cases of an advanced type (Type 1; two cases, Type 2; 1 case and Type 3 ; four cases). Histologic examination of biopsy specimens revealed well to poorly differentiated squamous cell carcinoma except for three advanced cases. Surgical resection was performed in twelve cases, and adjuvant chemotherapy was instituted in three cases and adjuvant radiotherapy in one case. Eight patients are alive without recurrence. A total of 89 cases of basaloid carcinoma reported in Japan, including our fourteen cases, were investigated clinicopathologically. The gross appearance of basaloid carcinoma commonly shows that of submucosal tumor and therefore preoperative diagnosis of the tumor is difficult to establish, culminating in a highly malignant potential due to its invasion into lymphatic and blood vessels. These days, long time survival has been reported in case of early-stage basaloid carcinoma. Investigation into histogenesis and growing pattern of basaloid carcinoma based on histopathological evidence, will therefore be helpful for better diagnosis and treatment of the tumor.
