2007 Volume 49 Issue 12 Pages 2972-2977
The patient was a 71-year-old woman who underwent hepatic arterial infusion chemotherapy using fluorouracil (5-FU) for recurrent liver metastasis of colon cancer. Abdominal CT showed pseudoaneurysm at the base of the gastroduodenal artery after 4 months. Further abdominal CT 11 months after starting 5-FU showed development of the pseudoaneurysm and dislocation of a catheter tip into the gastric antrum, but the patient remained asymptomatic, so no treatment was performed. Massive hematemesis occurred 14 months after starting 5-FU from pseudoaneurysm rupture into the duodenal bulb. Pseudoaneurysm underwent coil embolization, which stopped bleeding. Several days later, the catheter tip was removed using a 2-channel endoscope. Various complications related to intrahepatic arterial infusion chemotherapy have been reported, but the complications described here are rare and have not previously been reported. Since unexpected complications could occur, careful follow-up is warranted after hepatic arterial infusion chemotherapy.
