RAPID DEVELOPMENT OF PRIMARY GASTRIC ANAPLASTIC LARGE CELL LYMPHOMA AFTER H. PYLORI-ERADICATION THERAPY

Abstract

A 74-years old male who was pointed out atypical lymphocytes in mucosal specimen sampled from gastric erosion was introduced to our hospital for further evaluation. Initial endoscopic examination revealed erosive change with H. pylori-associated gastritis. Triple therapy for H. pylori was then performed and successfully eradicated. 2^nd endoscopy (3M later) revealed irregular gastric ulcer but no malignancy was histologically detected. However, type 2-like ulcer lesion appeared at 3^rd endoscopic examination (6M later). Histological examination revealed deep infiltration of CD30-positive atypical lymphocytes. Since lymphoma lesion was not detected in the other organ, we diagnosed anaplastic large cell lymphoma (ALCL) with gastric origin. ALCL originated from gastrointestinal tract is reportedly rare in non-Hodgikin T-cell lymphomas. Although malignant transformation of gastric B-cell MALT lymphoma after H. pylori-eradication therapy has been reported, rapid development of ALCL after H. pylori-eradication has not been reported so far.