Antimicrobial therapy for abdominal infection in ICU

Abstract

There were few studies that assessed the relationship between antibiotic therapy and prognosis in severe abdominal infection patients whatever the infection sources were controlled or not to evaluate the appropriate antibiotic therapy. We retrospectively investigated patients' characteristics, culture results, antibiotic therapy and prognosis with medical records of 86 abdominal infection patients admitted in our ICU from April 2013 to March 2016. In an univariate analysis, increased 28-day mortality was associated with multi-antibiotic administration at the first, increased total duration of antibiotic therapy, and high rate detection of antibiotic-resistant bacteria, and multi-antibiotic administration at the first and detection of antibiotic-resistant bacteria also remained in the multivariate analysis. Further studies of larger sample size are needed to evaluate the effect of multi-drug use and the type of drug resistance.