The role of platelet derived microvesicles in cell to cell communication during sepsis

Abstract

Over the last decades, it has become clear that platelets play an important role in the immune response in sepsis. Platelet derived microvesicles share certain characteristics with platelets, and also it acts as a mediator in cell to cell communication. It has been brought into the spotlight the platelet derived microvesicles deliver microRNA to the other cells and induce RNA Interference. Further studies are warranted to investigate the specific roles of the microRNAs in the pathogenesis of sepsis and the mechanism of delivery system.