Clostridioides difficile infections in solid organ transplantation

Abstract

Solid organ transplantations have led to high frequency of Clostridioides difficile infections (CDIs). In patients with kidney transplantation, the frequency of CDI has been lower than those with other solid organ transplantations, such as liver, heart or pancreas transplantations. The episode of CDIs mostly have been reported within one month after any transplantations. Age, antimicrobials or immunosuppressants might be highly associated with CDIs. Since the incidences of relapsed CDI have reported to be 29-50％ in patients with heart or lung transplantations, prophylactic administration with VCM or fecal microbial transplantation therapy has been studied against those patients.