Comparison of the preventive effect of surgical site infection as skin antisepsis between olanexidine gluconate and povidone–iodine for the patients undergoing hepatectomy

Abstract

【Purpose】This study was aimed to evaluate the preventive effect of olanexidine gluconate (OLG) for the development of surgical site infection (SSI) in patients with hepatectomy. 【Methods】This study included a total of 582 patients undergoing hepatectomy without biliary reconstruction or other organs resection. For preoperative skin antisepsis, 10％ povidone–iodine (PVP–I group) was used in 465 patients, whereas 1.5％ OLG was used in 117 patients (OLG group). Propensity score matching was conducted to adjust for confounding factors between the two groups. 【Results】After propensity score matching, the incidence rate of SSI [9 patients (7.7%) vs. 6 patients (5.1%); P ＝ 0.60], incisional SSI [1 (0.9%) vs. 2 (1.7%); P ＞0.99], and organ/space SSI [9 (7.7%) vs. 5 (4.3%); P ＝ 0.41] were comparable between the OLG and PVP–I groups. There was no significant difference in the incidence rate of MRSA infection [1 (0.9%) vs. 2 (1.7%); P ＞0.99］. 【Conclusions】OLG had similar preventive effect for the SSI development with PVP–I in patients with hepatectomy.