Abstract
In recent years, the effectiveness of continuous local antibiotics perfusion (CLAP) for bone and soft tissue infections has been increasingly reported. This study aimed to investigate the safety and efficacy of CLAP in 36 cases conducted at our institution. Safety evaluation included monitoring renal function, maximum gentamicin (GM) blood concentration, ototoxicity presence, and incidence of non-union. Efficacy assessment involved the remission rate of infections and the duration required for infection control. No significant differences in renal function were observed before and after CLAP, and the average maximum GM blood concentration was 0.75 μg/mL. Drug-related renal dysfunction was observed in one case, and no incidence of ototoxicity or other adverse events was detected. Two cases developed non-union. The infection remission rate was 86％ (12/14 cases) in the prophylactic group and 100％ (22/22 cases) in the treatment group. The average duration until infection remission in the treatment group was 11.5 days. These findings from the 36 cases of CLAP performed at our hospital demonstrate a high level of safety and efficacy.
