General Medicine
Online ISSN : 1883-6011
Print ISSN : 1346-0072
ISSN-L : 1346-0072
Case Report
Chronically Elevated Myeloperoxidase Antineutrophil Cytoplasmic Antibody Levels in an Asymptomatic 91-year-old Patient
Sayako MaedaJunko YabuuchiShinya OnoTetsuya MakiishiKunihiko Hirose
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2014 Volume 15 Issue 1 Pages 59-62

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Abstract
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated glomerulonephritis is commonly diagnosed in elderly patients with acute kidney injury (AKI). Prompt diagnosis and rapid initiation of appropriate therapy are essential to avoid the development of ANCA-associated vasculitis, which can be a life- and organ-threatening disease. We report a rare case of a 91-year-old male with a high MPO-ANCA titer, who took allopurinol, and showed no symptoms for >20 months, following which sudden AKI and severe bronchial asthma necessitated hemodialysis and steroid administration. Chronically elevated ANCA titers should be examined for causes and followed up to limit the risk of subsequent disease development.
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© 2014 Japan Primary Care Association
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