Abstract
Our study was executed with the intention of clarifying the relationship between arteriosclerosis of the gastric wall and gastric lesions. Clinical and histopathological studies were performed on 80 cases more than 60 years of age, consistd of 24 cases of gastric ulcer, 13 cases of duodenal ulcer, 16 cases of depressed type early gastric cancer, 13 cases of protruded type and 14 cases of no gastric lesions.
Resected stomach was cut into 9 pieces for histological study, on the small curvature, anterior wall and posterior wall, dyeing with hematoxylin Eosin stain and Weighert's elastica Van Gieson stain.
We graded the sevirity of arteriosclerosis of gastric wall according to Deguchi's classification and determined the degree of atrophy of the gastric mucosa in accordance with Hirahuku's classification modified by us.
The results were as follows.
1) The relationship could be sugested between arteriosclerosis of the gastric wall and atherosclerosis of the aorta.
2) The degree of arteriosclerosis of the gastric wall was highest in both gastric ulce4 and duodenal ulcer and lowest in early gastric cancer.
3) In gastric ulcer, arteriosclerosis of the gastric wall was related with ulceration of gastric mucosa by leading the atrophy of gastric mucosa and by reducing the mucosal resistance.
4) In duodenal ulcer, arteriosclerosis of gastric wall is not related with duodenal ulceration, which is much indebted to gastric mucosal resistance
5) In early gastric cancer, gastric mucosa easily fall into atrophic change by only low grade arteriosclero sis of gastric wall and gradually transform into malignancy oweing to vigorous ability of regeneration and proliferation.
6) As one grows older, atrophic border and intermediate zone rise together on gastric mucosa but the width of intermediate zone increase becuase of slow disappearance of fundic glands.
