1983 Volume 20 Issue 6 Pages 447-453
The concentrations of plasma total and HDL cholesterol and apoprotein A-I were determined for a month in 13 patients during the course of acute myocardial infarction (AMI). Since the fifth till fourteenth day after the onset, mean concentrations of plasma HDL cholesterol and apoprotein A-I decreased significantly from the levels of those in the first day. No significant changes were observed in the levels of total cholesterol and VLDL, LDL cholesterol (total cholesterol minus HDL cholesterol) during the course. The levels of VLDL, LDL cholesterol/HDL cholesterol ratio (cholesterol ratio) elevated since the seventh till fourteenth day. A negative correlation was seen between the lowest levels of HDL cholesterol and the highest levels of GOT or LDH in each patient.
AMI patients were classified into two groups according to HDL cholesterol levels; one with decreased HDL cholesterol (over 30%) the other without the change during the course. The numbers of the patients who suffered from angina pectoris befor the onset of AMI were only different between the two groups: the occurrence of angina was 7/9 in the group with decreased HDL cholesterol and 0/4 in the other group.
The results indicate that decrease in the levels of plasma HDL cholesterol during AMI reflects the severity of coronary sclerosis. The determination of the levels of plasma HDL cholesterol during AMI course is useful in order not only to estimate reliable cardiovascular risk factor, but also to understand the grade of pathological condition.