Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Print ISSN : 0300-9173
Hyperlipidemia in Pregnancy and Influence of Weight Change after Delivery on Total Cholesterol
Osamu MizunoTatsuo ToriumiNorio TsutsumiKiyoshi MaejimaYuzo ShinozakiYoshiki Otani
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1983 Volume 20 Issue 6 Pages 463-468


There is general agreement that serum triglyceride (TG) increases progressively throughout pregnancy. Increased serum total cholesterol (TC) during pregnancy has also been reported. The mode of rise in serum TC during pregnancy has been somewhat different in various reports. It is uncretain whether the weight loss after delivery influences serum TC or not.
Forty-five normal women after 32nd week of pregnancy were studied who had obvious hypercholesterolemia (TC≥300mg/dl). The subjects were divided into two groups-Groups A and B-according to the maximal level of TC (TCmax) during pregnancy. In Group A (TCmax<350mg/dl) 22 subjects were examined, in Group B (TCmax≥350mg/dl) 23, respectively. The duration between 32nd and 40th week of pregnancy was separated into three periods: from 32nd to 34th week of pregnancy (Period I), from 35th to 37th (Period II) and from 38th to 40th (Period III). In each Group A or B TC, HDL-cholesterol (HDL-C), Atherogenic index ((TC-HDL-C)/HDL-C, AI) and TG were studied. In each Group A or B TC was measured at intervals of 4 to 6 weeks post-partum until TC was below 250mg/dl.
Age of the pregnant woman, relative body weight before pregnancy, weight gain during pregnancy, degree of weight gain during pregnancy or birth weight of the child was not significantly different between Groups A and B.
In Group A TC unchanged and in Group B TC increased from 362±37 (SD) mg/dl at Period I to 378±26mg/dl at Period III. At Period I HDL-C in Group B was significantly higher than that in Group A (81.1±19.9 vs 67.6±13.1mg/dl, p<0.02). At each Period II or III AI in Group B was slightly higher than that in Group A. But AT was not significantly different between Groups A and B at each period. TG in Group A increased gradually from Period I to Period III. In Group B TG increased progressively, especially TG at Period III was significantly higher than TG at Period I (385±190 vs 272±75mg/dl, p<0.02). In 16 of the 22 post-partum women in Group A (72.7%) TC was below 250mg/dl within 10 weeks after delivery and in the same duration 10 of the 23 subjects in Group B (43.5%) reached that level of TC. This difference was significant (72.7 vs 43.5%, p<0.005). The average weekly weight loss of the subject in each group whose TC was below 250mg/dl within 10 weeks post-partum was greater than that of the subject whose TC reached 250mg/dl more than 11 weeks post-partum (Group A: 1.2±0.4 vs 0.6±0.2kg, p<0.005, Group B: 1.0±0.2 vs 0.7±0.2kg, p<0.01).
It was demonstrated that change in TC, HDL-C, AI or TG between Groups A and B was somewhat different. Although the reason of this difference was not clear, metabolic and endocrine factors might influence and diet might be additional factor. After delivery the rapid weight loss might bring rapid recovery of TC.

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